FINAL PROJECT PROPOSAL: Magnus Opus and Exigence > Immune and Inflammatory Role of B lymphocytes in Type 2 Diabetes

Audience: This paper is a research proposal for my research laboratory in the Department of Cell Biology and Molecular Genetics at the University of Maryland. I am applying for a fellowship from the Howard Hughes Medical Institute to receive lab funding and a personal stipend to be able to pursue my research project.

Context: Type 2 Diabetes (T2D) is a chronic disease characterized by hyperglycemia and hyperinsulinemia due to insulin resistance. Historically, T2D has been ascribed to risk factors such as inactivity, poor diet, and obesity. However, more recent research indicates that immunological components likely contribute to the pathogenesis of the disease. B-lymphocytes have been shown to play a critical role in initiating autoimmunity in the context of obesity-associated insulin resistance. Delineation of how B-lymphocyte autoimmunity contributes to T2D leads to better understanding of the causes of the disease. The recent increases in diabetes incidence and prevalence call for fundamental understanding of mechanisms underlying the development of the disease, to generate new strategies for effective prevention and treatment.

Purpose: The purpose of this research proposal is to provide an abstract and background for my research project. I discuss preliminary research that I have obtained to provide an ethos approach as to the feasibility of my proposal. The paper also describes the significance of my research, and details the experimental aims and the specific experimental methods that I plan to perform in order to successfully complete my research aims.

Document Type: Lab Documentation/Research Proposal
April 21, 2017 | Unregistered CommenterED
E, fascinating! I appreciate that research is looking at the sub types of diabetes, other than just TYPE 2 and TYPE 1. Do you know about the other types? MODY, LADA, Type 1.5? You may want to include a brief taxonomy of the types -- many with genetic components, as well as immunological profiles.

Be sure to ask your PI about the elements of a strong proposal. Also, look at the HH guidelines for UMCP undergraduate research. I am happy to help you meet their standards for this proposal.
April 23, 2017 | Registered CommenterMarybeth Shea