MbShea@PWP@English@UMCP

ABSTRACT: This literature review closely examines scientific research that has been conducted on bioelectric wound dressings. Bioelectric wound dressings have the ability to generate an electrical current to mimic the physiological current that is produced at the site of a wound. The mechanisms by which wound healing is initiated will have increased healing rates leading to faster recovery. The bioelectric dressings are effective against MDR bacteria and bacterial biofilms. Biofilms are cohesive structures of single or multi-species bacteria that have a mutual symbiotic relationship. Biofilms are extremely difficult to treat, especially when some of the bacterial species found in the biofilm are antibiotic resistant. This review highlights the efficacy of the bioelectric wound dressing against single-species biofilms, multi-species biofilms, and MDR bacteria. The review shifts from explaining antimicrobial and re-epithelialization mechanisms of bioelectric dressings to clinical use in healthcare environments. Vomaris's bioelectric wound dressing, Procellera, is extremely cost effective for clinicians to use; costing approximately $17 per dressing. Procellera's ability to function without an external power source provides clinicians with a quick, optimal, antimicrobial method of treating the wound site. Procellera does not only show antimicrobial efficacy against MDR bacteria and biofilms, it also speeds up wound healing and does not require an external power source to generate an electrical current. Bioelectric dressings use silver as the main antimicrobial agent. The end of the document addresses the limitations of bioelectric wound dressings by discussing the emergence of silver resistance genes.
WC= 242

READER'S PROFILE: I imagine a reader that believes silver can be toxic as a topical agent or lead to silver resistance genes if not toxic.

READER'S RESPONSE: It seems to me that applying topical silver over a large wound may in fact be very toxic if silver enters the bloodstream. Is it possible for the silver and zinc particles to enter the bloodstream? If not, then I will bring up my second point. If the emergence of silver resistance genes are due to consistent use of silver as a microbial agent, the bioelectric dressing will eventually lose its efficacy against MDR bacteria and biofilms. Bacteria will not only be multidrug-resistant but silver-resistant as well.

S -- what is the likelihood of this gene revision? Low? Silver is often seen as way to circumvent antibiotic resistance. Spend some time on this.

As for "blue man" colloidal silver problem, comment on dose and ingestion. Start here but go to authoritative sources:
https://en.wikipedia.org/wiki/Argyria

Also, say "an emerging option in wound car" because THE FUTURE overstates....we have other interesting ideas including honey wound dressings, among others.