FINAL PROJECT: Abstract and Reader's Reponse > Guide to Antibody-Drug Conjugate Experimentation at MedImmune

Abstract:
I have written a workplace document that details typical professional lab etiquette, background on antibody-drug conjugates, (ADCs) and experimental instructions on how to test ADCs for hydrophobicity. ADCs are a relatively new cancer-fighting drug; ADCs combine the targeting technique of monoclonal antibodies with the cancer killing ability of strong cytotoxic drug payloads.
The guide will also include how to approach a professional lab, which can be an intimidating place. The balance between asking questions and learning through your own actions can be tricky. If the project in question were a menial task I would always try on your own and then get feedback after, but be sure you are able to justify the steps taken to your supervisor so they can explain what went well and what needs work. Professional labs incorporate recent scientific articles, so one must be proficient in understanding high level science writings.
Finally, the guide will cover how hydrophobicity affects ADC efficacy, and how to run an experiment that tests hydrophobicity.

Reader Profile:
I imagine a reader that has worked in collegiate labs, and thinks the transition to a professional setting will be easy.
I imagine another reader who does not see the potential of ADCs.

Reader Response:
I have already worked in lab on a campus for three years, but it seems there is a bit more involved on the professional scale. The background knowledge needed to succeed in the biopharmaceutical field seems overwhelming. Will I ever be reach the knowledge level required to work independently?

ADCs seem like a powerful method of cancer treatment, but how much room for growth is there? What is holding back the advancement of ADCs? In my opinion ADCs seem too unpredictable to become the new standard cancer treatment.
December 10, 2015 | Unregistered CommenterPeter Davis
P--looks like a plan. Do you need to talk about lab safety training? What about confidentiality?
December 11, 2015 | Registered CommenterMarybeth Shea