MbShea@PWP@English@UMCP

The mechanisms underlying the pathogenesis of schizophrenia remain unknown. However, a large volume of research supports the notion that schizophrenia is an extremely heritable disorder. Recent findings strongly support variations within chromosome 6, and more specifically the major histocompatibility complex class I (MHC I). The alleles of the complement component 4 (C4A and C4B) genes that comprise a portion of MHC I are highly implicated in the development and manifestation of schizophrenia. Extensive research also supports the pathogenic contribution of variants in the glycogen synthase kinase 3 (Gsk3α and Gsk3β) genes. Elucidating the mechanistic relationships between the genes of interest and endophenotypes indicative of schizophrenia will provide a basis for novel therapeutic treatments in the coming future. Data suggests that the C4 genes and Gsk3 genes provide possible targets for future pharmaceuticals or therapies.

D -- count out these gene cluster drivers? Are you looking at two or three gene profiles?

Reluctant reader? Reader response?