MbShea@PWP@English@UMCP

The mechanisms underlying the pathogenesis of schizophrenia remain unknown. However, a large volume of research supports the notion that schizophrenia is an extremely heritable disorder. As a result of this fact, it is highly accepted amongst researchers that two candidate genes play an essential role in the progression of schizophrenia. Recent findings support variations within chromosome 6, and more specifically the major histocompatibility complex class I (MHC I). The alleles of the complement component 4 (C4A and C4B) genes that comprise a portion of MHC I are highly implicated in the development and manifestation of schizophrenia. The proteins encoded by the genes of interest are essential components in the body’s immune response; ultimately, providing support for the notion that schizophrenia may stem from an autoimmune element. Extensive research also supports the pathogenic contribution of variants in the glycogen synthase kinase 3 (Gsk3α and Gsk3β) genes. Proteins encoded by the Gsk3 genes play an important role in synaptic pruning and axonal modification, adding further support for the role of neuronal development in the manifestation of psychiatric disorders such as schizophrenia. Elucidating the mechanistic relationships between the genes of interest and endophenotypes indicative of schizophrenia will provide a basis for novel therapeutic treatments in the coming future. Data suggests that the C4 genes and Gsk3 genes provide possible targets for future pharmaceuticals or therapies. Schizophrenia treatment is a developing field that will continue to progress over the next two to three decades with the C4 and Gsk3 genes at the forefront.

WC=250
READER'S PROFILE: I imagine a reader who will not find the research and the genetic implications satisfying with respect to the etiological factors of schizophrenia.

READER'S RESPONSE: The fact that you are analyzing the data of only two genes does not provide an accurate depiction of the overwhelming complexity underlying the development of schizophrenia. There are substantial environmental factors that contribute to the manifestation of the disease, and a myriad of other genes implicated in the development of schizophrenia. Why not select more to review? The information being reviewed also contributes no information regarding diagnosis or therapies that can be implemented in the foreseeable future.

(REVISED VERSION) Sorry, I forgot to include the reader's response.