FINAL PROJECT: Abstract and Reader's Reponse > Impact of EVs
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Extracellular vesicles as emerging targets in cancer: Recent development from bench to bedside.
Wu K, Xing F, Wu SY, Watabe K.
Biochim Biophys Acta. 2017 Dec;1868(2):538-563. doi: 10.1016/j.bbcan.2017.10.001. Epub 2017 Oct 18. Review.
PMID: 29054476
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Select item 27810172
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Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease.
Huang-Doran I, Zhang CY, Vidal-Puig A.
Trends Endocrinol Metab. 2017 Jan;28(1):3-18. doi: 10.1016/j.tem.2016.10.003. Epub 2016 Oct 31. Review.
PMID: 27810172
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Select item 23584393
3.
Extracellular vesicles: biology and emerging therapeutic opportunities.
EL Andaloussi S, Mäger I, Breakefield XO, Wood MJ.
Nat Rev Drug Discov. 2013 May;12(5):347-57. doi: 10.1038/nrd3978. Epub 2013 Apr 15. Review.
PMID: 23584393
----
Pub med listed article are sometimes used as a proxy for lines of inquiry that can be submitted to NIH for funding. Ask me about this background condition in pharmacology research.
Do you have these sources in your paper?:
Extracellular vesicles as emerging targets in cancer: Recent development from bench to bedside.
Wu K, Xing F, Wu SY, Watabe K.
Biochim Biophys Acta. 2017 Dec;1868(2):538-563. doi: 10.1016/j.bbcan.2017.10.001. Epub 2017 Oct 18. Review.
PMID: 29054476
Similar articles
Select item 27810172
2.
Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease.
Huang-Doran I, Zhang CY, Vidal-Puig A.
Trends Endocrinol Metab. 2017 Jan;28(1):3-18. doi: 10.1016/j.tem.2016.10.003. Epub 2016 Oct 31. Review.
PMID: 27810172
Similar articles
Select item 23584393
3.
Extracellular vesicles: biology and emerging therapeutic opportunities.
EL Andaloussi S, Mäger I, Breakefield XO, Wood MJ.
Nat Rev Drug Discov. 2013 May;12(5):347-57. doi: 10.1038/nrd3978. Epub 2013 Apr 15. Review.
PMID: 23584393
----
Pub med listed article are sometimes used as a proxy for lines of inquiry that can be submitted to NIH for funding. Ask me about this background condition in pharmacology research.
December 10, 2017 |
Marybeth Shea
Marybeth Shea
Existing research has described the involvement of extracellular vesicles in numerous common diseases. To better understand a broad range of disease progression, the impacts and mechanism of extracellular vesicles needs to be further investigated. From heart disease to osteoarthritis, extracellular vesicles carry various different cargos, from nucleic acid to small proteins, that may further the disease. This review explores the broad range of disease that incorporates extracellular vesicles, and the potential of extracellular vesicles as therapeutics. Extracellular vesicles, due to their capacity to carry cargo, are ideal in drug delivery. Since secretion of extracellular vesicles is very common in human cells, it is important to explore the therapeutic uses. The therapeutic efficacy of vesicles may depend on the source of the vesicle and the cargo with in the vesicle. Further research is needed to determine all the multifaceted effects of extracellular vesicles, including the potential as a future treatment.
Reader’s profile: A drug delivery researcher in a clinical setting reviewing this paper.
Reader’s perspective: How significant of a contribution do extracellular vesicles make in disease progression? How will this type of therapy compare to treatments currently available for various diseases? I would have to do more investigation into extracellular vesicles.